Fig. 7: Effects of Gdf15 on autophagy in cells. | Communications Biology

Fig. 7: Effects of Gdf15 on autophagy in cells.

From: Stress-responsive Gdf15 counteracts renointestinal toxicity via autophagic and microbiota reprogramming

Fig. 7: Effects of Gdf15 on autophagy in cells.

Control or Gdf15-deficient cells (HCT-8 (a) or HK-2 (b) cells) were transfected with pDEST-CMV mCherry-GFP-LC3B WT. At 24 h after transfection, cells were treated with vehicle or 10 μmol/L cisplatin (CP) for 48 h. Cells were observed under the confocal microscope to monitor the pH-responsive autophagic flux (Magnification, 400×; Scale bar(s), 10 μm). The quantitation analysis was shown as plots with Tukey whiskers (lower graphs) and all datapoints (circles). Different letters with bars represent significant differences between groups (p < 0.05). Gdf15, growth differentiation factor 15.

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