Table 2 Molecular markers of P. falciparum antimalarial resistance observed at frequencies below 5% in Mozambique.
North | Center | South | |||||
|---|---|---|---|---|---|---|---|
n | % | n | % | n | % | ||
pfcrt | |||||||
C72S | wt | 302 | 100 | 424 | 100 | 928 | 100 |
M74I | wt | 302 | 100 | 425 | 100 | 918 | 98.7 |
mut | 0 | 0 | 0 | 0 | 10 | 1.1 | |
mix | 0 | 0 | 0 | 0 | 2 | 0.2 | |
N75E | wt | 302 | 100 | 425 | 100 | 918 | 98.6 |
mut | 0 | 0 | 0 | 0 | 10 | 1.1 | |
mix | 0 | 0 | 0 | 0 | 3 | 0.3 | |
K76T | wt | 302 | 100 | 425 | 100 | 917 | 98.7 |
mut | 0 | 0 | 0 | 0 | 10 | 1.1 | |
mix | 0 | 0 | 0 | 0 | 2 | 0.2 | |
Artemisinin-resistance genetic background | |||||||
V127M (pfarps10) | wt | 304 | 100 | 437 | 100 | 965 | 100 |
D128Y/H (pfarps10) | wt | 225 | 100 | 386 | 100 | 596 | 100 |
D193Y (pffd) | wt | 298 | 100 | 415 | 100 | 901 | 100 |
N326S (pfcrt) | wt | 292 | 99.3 | 413 | 99.8 | 932 | 99.8 |
mix | 2 | 0.7 | 1 | 0.2 | 2 | 0.2 | |
I356T (pfcrt) | wt | 297 | 100 | 419 | 100 | 924 | 100 |
T484I (pfmdr2) | wt | 297 | 100 | 412 | 100 | 856 | 100 |
Plasmepsin 2/3 breakpoint | |||||||
wt | 117 | 99.2 | 180 | 100 | 225 | 99.6 | |
Duplication | 1 | 0.8 | 0 | 0 | 1 | 0.4 | |
pfexo | |||||||
E415G | wt | 241 | 100 | 300 | 100 | 853 | 100 |
pfmdr1 | |||||||
N86Y | wt | 290 | 99.7 | 416 | 100 | 888 | 98.9 |
mut | 1 | 0.3 | 0 | 0 | 7 | 0.8 | |
mix | 0 | 0.0 | 0 | 0 | 3 | 0.3 | |
D1246Y | wt | 285 | 100 | 396 | 100 | 837 | 99.9 |
mix | 0 | 0 | 0 | 0 | 1 | 0.12 | |
pfdhfr | |||||||
I164L | wt | 294 | 100 | 412 | 99.8 | 864 | 100 |
mix | 0 | 0 | 1 | 0.24 | 0 | 0 | |
pfdhps | |||||||
A581G | wt | 287 | 99.7 | 376 | 99.5 | 824 | 100 |
mut | 0 | 0.0 | 1 | 0.3 | 0 | 0 | |
mix | 1 | 0.3 | 1 | 0.3 | 0 | 0 | |
A613S/T | wt | 281 | 98.3 | 375 | 99.5 | 827 | 100 |
mut | 1 | 0.3 | 0 | 0.0 | 0 | 0 | |
mix | 4 | 1.4 | 2 | 0.5 | 0 | 0 | |
