Fig. 1: Altered frequency of IL-17A+ CD4 T-cell subset in CKO mice in a steady state. | Communications Biology

Fig. 1: Altered frequency of IL-17A+ CD4 T-cell subset in CKO mice in a steady state.

From: SENP2 restrains the generation of pathogenic Th17 cells in mouse models of colitis

Fig. 1: Altered frequency of IL-17A+ CD4 T-cell subset in CKO mice in a steady state.The alternative text for this image may have been generated using AI.

a–c FACS showing the frequency of IFNγ+ or IL-17+ CD4+ T cells in the spleen and cLN of WT and CKO mice (a), and the statistical analysis of indicated CD4+ subsets in the spleen (b) and cLN (c) of WT and CKO mice. d FACS showing the frequency of various indicated Th subsets differentiated in vitro on day 5. e, f The Senp2 mRNA (e) and protein (f) levels on day 5 of each indicated Th subset culture. Results in (e) are normalized to actin mRNA and then compared with Th0. Results in (b, c, e) are mean ± SD (n = 3−5). Statistical analysis was done by Student’s t test in (b, c) and one-way ANOVA in (e). *P < 0.05.

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