Fig. 4: The gut bacterial composition was altered in DSS-treated Senp2-deficient mice.
From: SENP2 restrains the generation of pathogenic Th17 cells in mouse models of colitis
a, b 16 S RNA sequencing of the fecal microbiota of WT and CKO mice in a steady state (a) and on day 14 after DSS induction (b). Results were analyzed by principal component analysis (PCA). c, d The fecal bacterial composition in a steady state (c) and in DSS-treated (d) WT and CKO mice at the genus level. e The levels of Bacteroides, Clostridium, and Escherichia-Shigella in the fecal microbiota from DSS-treated WT and CKO mice on day 14. Results are mean ± SD (n = 8 in WT and CKO mice in (a, b); n = 5 in WT and n = 6 in CKO in (c–e)). Statistical analysis was done by Student’s t test. *P < 0.05, **P < 0.005.
