Fig. 4: Ligand-receptor analysis revealed that GTS-21 increases macrophage-macrophage interactions. | Communications Biology

Fig. 4: Ligand-receptor analysis revealed that GTS-21 increases macrophage-macrophage interactions.

From: Alpha 7 nicotinic acetylcholine receptors signaling boosts cell-cell interactions in macrophages effecting anti-inflammatory and organ protection

Fig. 4

a Plasma TNF-α level in mice subjected to single-cell RNA-seq. b Heatmap of the predicted count of ligand-receptor interactions between various immune cells in the spleen using CellPhoneDB. c, d Dot plot of the predicted ligand-receptor (LR) interactions from the macrophage side. LR pairs are shown in (c) when macrophages are ligands, whereas in (d) when macrophages are receptors. e Dot plot of the predicted ligand-receptor interactions focusing on the macrophage. GTS-21 3-(2,4-Dimethoxybenzylidene)- anabaseine dihydrochloride, LPS lipopolysaccharide, Veh vehicle control.

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