Fig. 7: Splenectomy abolished the GTS-21 mediated anti-inflammatory and kidney protective effects in WT mice. | Communications Biology

Fig. 7: Splenectomy abolished the GTS-21 mediated anti-inflammatory and kidney protective effects in WT mice.

From: Alpha 7 nicotinic acetylcholine receptors signaling boosts cell-cell interactions in macrophages effecting anti-inflammatory and organ protection

Fig. 7: Splenectomy abolished the GTS-21 mediated anti-inflammatory and kidney protective effects in WT mice.

a Experimental design. Seven days prior to GTS-21 and LPS administration, the WT mice underwent splenectomy or sham operation (n = 6–9 in each group). b Plasma TNF-α levels and anti-inflammatory effect of GTS-21. c Ngal and Kim-1 expression with following GTS-21 treatment. d Plasma TNF-α levels in CD4 + T cell-depleted mice with or without GTS-21. Plasma TNF-α was decreased in the GTS-21-treated mice (P = 0.003). *P < 0.05, (two-way ANOVA followed by Tukey’s post hoc test (b), unpaired t test (c, d)). WT wild-type, GTS-21 3-(2,4-Dimethoxybenzylidene)- anabaseine dihydrochloride, LPS lipopolysaccharide, TNF-α tumor necrosis factor α, SPLX splenectomy, ANOVA analysis of variance.

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