Fig. 7: Effect of suppression of resR/mcdR and rplN on post-antibiotic recovery of Mtb.

a Time-kill kinetics of the resR/mcdR(−). Time-kill kinetics was examined in response to treatment with isoniazid (INH), rifampicin (RIF), streptomycin (STR), and levofloxacin (LEV). The MDK₉₉ by each drug, after exposure to 10× MIC is depicted by the dashed line. b Post-antibiotic recovery dynamics of resR/mcdR(−). Representative images, captured between 13 and 21 days of incubation, depict the post-antibiotic recovery dynamics of Mtb depleted with resR/mcdR. c Time-kill kinetics of the rplN(–). Time-kill kinetics was examined in response to treatment with 10× MIC of different drugs, as mentioned in a. The MDK₉₉ by each drug is depicted by the dashed line. d Post-antibiotic recovery dynamics of rplN(–). Representative images, captured between 13 and 21 days of incubation, depict the post-antibiotic recovery dynamics of Mtb depleted with rplN. Scale bars in b, d are shown for size reference.