Fig. 2: Two-sample Mendelian randomization analysis results of the causal effects of nine types of serum interleukin levels on kidney function. | Communications Biology

Fig. 2: Two-sample Mendelian randomization analysis results of the causal effects of nine types of serum interleukin levels on kidney function.

From: Mendelian randomization uncovers a protective effect of interleukin-1 receptor antagonist on kidney function

Fig. 2

The causal estimates were derived from the UK Biobank and CKDGen genome-wide association study meta-analysis for log-transformed creatinine-based eGFR. The shapes indicate beta coefficients per standard deviation change in corresponding serum interleukin level, and error bars indicate the 95% confidence interval. a The rhombus, square, and circle shapes indicate estimates calculated from weighted median, MR-IVW, and MR-Egger, respectively. b The triangle, rhombus, square, and circle shapes indicate estimates calculated from the weighted median, ratio of coefficient, MR-IVW, and MR-Egger, respectively. eGFR estimated glomerular filtration rate, IL interleukin, 95% CI 95% confidence interval, MR-IVW multiplicative random-effects inverse-variance weighted.

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