Fig. 4: Examples of significant regional correlations between gene expression levels and diseases across three genes. | Communications Biology

Fig. 4: Examples of significant regional correlations between gene expression levels and diseases across three genes.

From: Regional genetic correlations highlight relationships between neurodegenerative disease loci and the immune system

Fig. 4

a BIN1 (chromosome 2) was significantly correlated with AD across various adaptive immune cell types. b SCIMP (chromosome 17) was significantly correlated with AD across B cells. c RAB7L1 (chromosome 1) was significantly correlated with PD in naive CD4 +T cells. ** = significant correlations (FDR < 0.01); · = nominally significant correlations; ns = non-significant correlations (p-value ≥ 0.05). AD Alzheimer’s disease, LBD Lewy body dementia, PD Parkinson’s disease, BMem Memory B cells, CD4ET CD4+ effector memory T cells; CD4NC CD4+ naive T cells; CD8ET CD8+ effector memory T cells; CD8NC CD8+ naive T cells. Source data found in Supplementary Data 2.

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