Fig. 4: Effects of suppressing PV neurons on spike timing and rate-based coding measures.
From: Parvalbumin neurons enhance temporal coding and reduce cortical noise in complex auditory scenes
a Performance based on ISI-distance, which measures differences between trains in instantaneous firing rate only (see “ISI-distance”). Paired t tests showed a significant decrease in performance for both clean (n = 43 configurations; P = 1.33e-08, d = 1.07) and masked (n = 18 configurations; P = 0.00371, d = 0.79) trials. b Performance based on RI-SPIKE-distance, which measures differences between trains in spike timing only (see “RI-SPIKE-distance”). Paired t tests showed a significant decrease in performance for both clean (P = 2.63e-08, d = 1.04) and masked (P = 0.0010, d = 0.32) trials. c Performance based on differences in total spike count between spike trains was near chance level, indicating that total spike count did not account for overall discrimination performance. Paired t tests showed a significant decrease in performance for clean trials (P = 0.0434, d = 0.32) but not for masked trials (P = 0.0656, d = 0.46). d Summary figure showing contributions from spike-distance measures presented in Fig. 3f and panels (a–c) on the same scale and axis, with circle markers representing performance during control trials and square markers representing performance during optogenetic trials. Changes in spike timing and instantaneous firing rate-based measures (RI-SPIKE and ISI, respectively) provide relatively high discrimination performance and show a significant decrease upon optogenetic suppression of PV neurons.
