Table 1 Ligand-binding interface residues of NOTCH1 EGF11−12 and NOTCH2 EGF11−12.

From: Mutations observed in somatic evolution reveal underlying gene mechanisms

 

Ligand-binding interface residues

NOTCH1 EGF11−12

413, 415, 418, 420, 421, 422, 423, 424, 425, 435, 436, 444, 447, 448, 450, 451, 452, 454, 466, 467, 468, 469, 470, 471, 475, 477, 478, 479, 480

NOTCH2 EGF11−12

418, 421, 424, 425, 426, 428, 429, 439, 440, 452, 454, 456, 470, 472, 473, 481

  1. NOTCH1 ligand-binding interface residues based on Supplementary Fig. S3 of ref. 23.
  2. Ligand-binding interface residues of NOTCH2 EGF11−12 from ref. 48.
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