Fig. 5: T cell differentiation brings about genome-wide changes in chromatin interactions. | Communications Biology

Fig. 5: T cell differentiation brings about genome-wide changes in chromatin interactions.

From: Multi-omic analysis reveals dynamic changes of three-dimensional chromatin architecture during T cell differentiation

Fig. 5: T cell differentiation brings about genome-wide changes in chromatin interactions.The alternative text for this image may have been generated using AI.

a Venn diagram shows number of loops in Naive and Th17 cells. b Aggregate peak analysis (APA) at 10-kb resolution plots display the average Hi-C signal at chromatin loops that are lost, gained, and common during differentiation from Naive to Th17. The enrichment value in the central pixel is displayed on top left for reference. c The boxplot shows the log2 normalized interaction frequency fold change (Th17/Naive) for the three groups in a. The boxplots are shown as median (line), interquartile range (box), and minimum to maximum data range (whisker). The p-values by unpaired Wilcoxon test, ***< 0.001. d Enrichment analysis of genes associated with E-P gained loops. e. The top two motifs within ATAC-Seq peaks associated with E-P loops.

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