Fig. 1: Cell correspondences between mouse and human EHT cells.
From: Cross-species transcriptomics reveals bifurcation point during the arterial-to-hemogenic transition
a HomologySeeker workflow. b Pearson correlation heatmap showing the relationship between mouse and human cell types, with colors representing Pearson correlation coefficients. Endo, endothelium section; Hemo, arterial/hemogenic section; Hema, hematopoietic section. c Top-left: Schematic of query projection. Bottom: Heatmap displaying projection scores of human cell types assigned new identities based on mouse reference. Columns represent human cells; rows represent mouse cell types; color intensity represents prediction scores. Unified: combined human cell type annotation; Origin: original human dataset annotation; Stage: cell timepoints. d UMAP visualization of human sub-clusters (C1–C10) post-unsupervised clustering. e Schematic of SingleCellNet model from (Tan et al.47). f SingleCellNet prediction scores of human cells using mouse cell types as a reference; higher scores indicate greater confidence. g Expression levels of marker genes across mouse cell types (upper panel) and human sub-clusters (lower panel). V, venous; A/Endo, arterial or endothelial; Hema, hematopoietic.
