Fig. 5: Cell fate choices during the pre-HE stage.
From: Cross-species transcriptomics reveals bifurcation point during the arterial-to-hemogenic transition
During mouse and human EHT, a specific subset of AECs differentiates into pre-HEs. In response to interactions between specific cell fate determinants (like CXCL12) and their corresponding receptors, pre-HEs may advance toward either a hemogenic or arterial fate. Those hemogenic precursors that acquire the CXCL12 signal can further develop into a hematopoietic population with multilineage differentiation capability aggregated in clusters. AEC arterial endothelial cell, pre-HE pre-hemogenic endothelium, HE hemogenic endothelium, IAC intra-aortic cluster.
