Fig. 2: Study design. | Communications Biology

Fig. 2: Study design.

From: Genome-wide association studies and fine-mapping identify genomic loci for n-3 and n-6 polyunsaturated fatty acids in Hispanic American and African American cohorts

Fig. 2: Study design.

Figure 2 shows the study design. GWAS of PUFAs was applied for each cohort stratified by HIS and AFA. Ancestry-specific GWAS meta-analysis and statistical fine-mapping were applied separately for HIS and AFA to identify the potential causal signals. Multiple follow-up analyses were conducted for the causal signals, including cross-ancestry replication, validation, chromatin contact analysis and integrative analyses.

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