Fig. 6: Genetic knockdown of Coch gene expression or pharmacological blockade of SFRP1 prevented myopia progression by increasing choroidal blood perfusion in the FDM model. | Communications Biology

Fig. 6: Genetic knockdown of Coch gene expression or pharmacological blockade of SFRP1 prevented myopia progression by increasing choroidal blood perfusion in the FDM model.

From: Targeting the cochlin/SFRP1/CaMKII axis in the ocular posterior pole prevents the progression of nonpathologic myopia

Fig. 6

The effects of cochlin shRNA and SFRP1 inhibitor on refraction (a) and AL (b) in the FDM model at 1 w and 6 w post induction (using data from treated eyes) were shown and compared using two-way ANOVA (n = 5–18). The effects of cochlin shRNA and SFRP1 inhibitor on refraction (c) and AL (d) in the FDM model at 1 w and 6 w post induction (using data of differences between two eyes) were also shown and compared using two-way ANOVA (n = 5–18). An en face illustration of OCTA on guinea pig choroid (e). A cross-sectional illustration of OCTA of the guinea pig choroid (f). Representative OCTA images of the guinea pig choroid at 1 w and 6 w following FDM induction (g). Choroidal blood perfusion was quantified from OCTA images (h) and compared using one-way ANOVA (n = 46–133). A schematic reference to the position of the examined posterior pole tissues (i). Representative HE staining images of ocular posterior pole tissues, including choroidal vasculature, at 1 w and 6 w following FDM induction (j). Scale bar = 50 μm. The area of the choroidal vessel lumen was quantified from the HE staining images (k) and compared by one-way ANOVA (n = 16–25). All data represent the mean ± SEM. *P < 0.05, **P < 0.01, ***P < 0.001. SFRP1 secreted frizzled-related protein 1, FDM form-deprived myopia, AL axial length, w week(s), OCTA optical coherence tomography angiography, HE hematoxylin and eosin.

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