Fig. 7: Molecular effects of intervening in the two actionable targets, cochlin and SFRP1, in the FDM model. | Communications Biology

Fig. 7: Molecular effects of intervening in the two actionable targets, cochlin and SFRP1, in the FDM model.

From: Targeting the cochlin/SFRP1/CaMKII axis in the ocular posterior pole prevents the progression of nonpathologic myopia

Fig. 7

Representative western blot of cochlin at 1 w (a) and 6 w (c) following myopic induction. The western blots were quantified in b and d. The cochlin protein levels were compared using one-way ANOVA (n = 4–7). Representative western blot of p-CaMKII and CaMKII at 1 w following myopic induction is shown in e. Quantification of the blots (f–h) was compared using one-way ANOVA (n = 6). Representative western blot of p-CaMKII and CaMKII at 6 w following myopic induction is shown in i. Quantification of the blots (j–l) was compared using one-way ANOVA (n = 6). All data represent the mean ± SEM. *P < 0.05, **P < 0.01, ***P < 0.001. NOR normal control, FDM form-deprived myopia, CaMKII Ca2+/calmodulin-dependent protein kinase II.

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