Fig. 8: The loss of Grin2a causes a transient change in action potential firing properties of CA1 PV cells. | Communications Biology

Fig. 8: The loss of Grin2a causes a transient change in action potential firing properties of CA1 PV cells.

From: Loss of Grin2a causes a transient delay in the electrophysiological maturation of hippocampal parvalbumin interneurons

Fig. 8: The loss of Grin2a causes a transient change in action potential firing properties of CA1 PV cells.The alt text for this image may have been generated using AI.

Representative action potential trains elicited by current injections depicted below each train to illustrate the maximum action potential firing frequency and the current required for depolarization-induced block of action potential firing for A Grin2a+/+, B Grin2a+/−, and C Grin2a−/− mice during development. D Maximum action potential firing frequencies show a significant main effect for both age (F2, 135 = 29.8; p < 0.0001; two-way ANOVA) and genotype (F2, 135 = 6.7; p = 0.0017; two-way ANOVA). E Currents required to reach depolarization-induced block of action potential firing show a significant main effect for both age (F2, 135 = 4.2; p = 0.017; two-way ANOVA) and genotype (F2, 135 = 5.4; p = 0.006; two-way ANOVA). Symbols are mean ± SEM. AP = action potential; depolarization block = current required to reach depolarization-induced block of action potential firing; *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001.

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