Fig. 2: Stat4fl/fLysMCreLdlr−/− mice exhibit improved glucose tolerance and response to insulin when challenged by feeding for 16 weeks with a HFD-C diet. | Communications Biology

Fig. 2: Stat4fl/fLysMCreLdlr−/− mice exhibit improved glucose tolerance and response to insulin when challenged by feeding for 16 weeks with a HFD-C diet.

From: Myeloid cell deficiency of the inflammatory transcription factor Stat4 protects long-term synaptic plasticity from the effects of a high-fat, high-cholesterol diet

Fig. 2

a Glucose tolerance test (GTT) and (b) insulin tolerance tests (ITT) at different time points from Stat4fl/fLysMCreLdlr−/− and Stat4fl/flLdlr−/− mice on HFD-C diet for 16 weeks starting at 8 weeks old (n = 8 biologically independent animals of each sex per genotype). Two-way ANOVA for repeated measures shows that GTT (genotype factor p = 0.0068, df = 10) and ITT (genotype factor p = 0.0118, df = 12) both exhibited significantly improved responses to glucose and insulin, respectively, in animals lacking full expression of Stat4, after mice were challenged by feeding of the HFD-C diet for 24 weeks. All error bars are standard error of the mean.

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