Fig. 4: Nanostring™ inflammation gene expression patterns in Stat4fl/fLysMCreLdlr−/− mice lacking Stat4, compared to control Stat4fl/fl Ldlr−/− mice, when fed a HFD-C diet for 16 weeks.
a–b Volcano plot and table showing significantly up (green) and down (purple) regulated genes in the hippocampus of Stat4fl/fLysMCreLdlr−/− versus age-matched control Stat4fl/fl Ldlr−/− mice fed the HFD-C diet for 16 weeks (from 8–24 weeks of age). Differentially expressed genes were determined as >1.5-fold difference with adjusted p value < 0.05. n = 3 biologically independent animals per group. c Dot plot shows the altered GO terms (FDR < 0.05) of biological processes and molecular functions identified using DAVID to be enriched under the different contrasts. Dot plot shows the up-regulated KEGG pathways (FDR < 0.1) enriched for different contrasts. The size of the dot is based on gene count enriched in the pathway, and the color of the dot shows the pathway enrichment significance. Dot plot shows the down-regulated GO terms (FDR < 0.05) of biological processes and molecular functions identified using WikiPathway analysis. The size of the dot is based on gene count enriched in the pathway, and the color of the dot shows the pathway enrichment significance.
