Fig. 5: Stat4fl/fLysMCreLdlr−/− versus age-matched control Stat4fl/fl Ldlr−/− mice at 3 weeks of age exhibit similar magnitude LTP at Schaffer collateral-CA1 synapses in hippocampus. | Communications Biology

Fig. 5: Stat4fl/fLysMCreLdlr−/− versus age-matched control Stat4fl/fl Ldlr−/− mice at 3 weeks of age exhibit similar magnitude LTP at Schaffer collateral-CA1 synapses in hippocampus.

From: Myeloid cell deficiency of the inflammatory transcription factor Stat4 protects long-term synaptic plasticity from the effects of a high-fat, high-cholesterol diet

Fig. 5

a Time course of LTP following three theta burst trains of stimulation (TBS ×3) of Schaffer collateral axons spaced 3 min apart in hippocampal slices from Stat4fl/fLysMCreLdlr−/− mice (open circles, each point mean ± SEM) versus control Stat4fl/fl Ldlr−/− mice (filled circles, each point mean ± SEM). b Mean ± SEM magnitude of LTP 60 min post-TBS, showing that Stat4fl/fLysMCreLdlr−/− slices (filled bars, n = 19 biologically independent slices, normalized LTP = 1.68 ± 0.092) exhibited unchanged LTP compared to control Stat4fl/fl Ldlr−/− slices (open bars, n = 16 biologically independent slices, normalized LTP = 1.65 ± 0.121, Student’s t-test, p = 0.8254, t = 0.2224, df = 33).

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