Fig. 3: Expression of BrafV600E in the intestinal epithelium induces persistent gene signatures related to CRC. | Communications Biology

Fig. 3: Expression of BrafV600E in the intestinal epithelium induces persistent gene signatures related to CRC.

From: BRAFV600E-mutated serrated colorectal neoplasia drives transcriptional activation of cholesterol metabolism

Fig. 3: Expression of BrafV600E in the intestinal epithelium induces persistent gene signatures related to CRC.

a GSEA showing changes in signatures associated with BRAFV600E-driven CRC 3 days and 6 months following tamoxifen induction. b GSEA showing changes in the Wnt signature 3 days and 6 months following tamoxifen induction. c GSEA showing enrichment in a poor-prognosis gene signature for BRAFV600E-drive CRC 6 months following tamoxifen induction. d GSEA showing dependence on MAPK pathway for the establishment of key gene signatures. Mice expressing BrafV600E for 3 days were treated with vehicle control or the MEK inhibitor PD184352 (MEKi). NES normalized enrichment score.

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