Fig. 6: Analysis of regulons associated with the transcription of the cholesterol metabolism genes in a human single-cell transcriptomic dataset. | Communications Biology

Fig. 6: Analysis of regulons associated with the transcription of the cholesterol metabolism genes in a human single-cell transcriptomic dataset.

From: BRAFV600E-mutated serrated colorectal neoplasia drives transcriptional activation of cholesterol metabolism

Fig. 6: Analysis of regulons associated with the transcription of the cholesterol metabolism genes in a human single-cell transcriptomic dataset.

a Regulon activity projected in UMAP space for the regulons associated with transcription factors (FOSL1, SP6, KLF16, NR2F1, CEBPB, CREB3) involved in the establishment of the cholesterol gene signature in the SSCs. b A network diagram generated with iRegulon in Cytoscape using the differentially expressed gene of the cholesterol biosynthesis signature in SSC identified by Seurat as an input. Circles indicate 21 significant genes, colored by avg_Log2FC. Octagons symbolize selected TFs (cut off >5 target genes) involved in the regulation of DEGs in the cholesterol biosynthesis signature. The edges represent connections between each of six transcription factors and their target genes and are colored based on the source of integration.

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