Fig. 7: Model proposing regulation of ICI-related autoimmune myocarditis by ANGPTL2 derived from cardiac fibroblasts.
From: ANGPTL2 promotes immune checkpoint inhibitor-related murine autoimmune myocarditis
In heart tissues, cardiac myofibroblasts express abundant ANGPTL2, when then promotes chemokine expression in myofibroblasts via integrin α5β1 signaling, enhancing recruitment of T cells and contributing to autoimmune inflammation.
