Fig. 7: A model for MJ1647-DNA-bridging and compaction by alternative DNA-binding modes.
From: DNA-bridging by an archaeal histone variant via a unique tetramerisation interface
MJ1647 bridges DNA by positioning the histone folds opposite each other with the TM adopting a conformation as predicted in the AlphaFold2 model (Fig. 4c). DNA compaction as observed in the TPM experiments (Fig. 3b) likely occurs via canonical histone dimer–dimer interactions. Such dimer–dimer interactions would require a rearrangement or breaking of the TM due to steric clashes (as indicated by the red question mark).
