Fig. 3: Muscimol protects mice against LPS-induced lethality.
From: Muscimol inhibits plasma membrane rupture and ninjurin-1(NINJ1) oligomerization during pyroptosis
a C57BL/6J mice were injected with 3 mg/kg muscimol, or PBS, followed by 10 mg/kg LPS. Mice were observed for clinical signs of illness and euthanized when overt signs of sepsis were observed. b Sera from mice injected with PBS, LPS alone, or muscimol + LPS were analyzed for the level of blood urea nitrogen (BUN). Data are combined values from three independent experiments, n = 23 mice per condition for LPS and muscimol + LPS, n = 5 uninfected mice. Statistics: (a) Mantel-Cox Log-rank test, (b) one-way ANOVA + Tukey’s multiple comparisons.
