Fig. 5: Modification of muscimol at positions 3 and 4 abolishes the inhibitory capacity of muscimol.
From: Muscimol inhibits plasma membrane rupture and ninjurin-1(NINJ1) oligomerization during pyroptosis
a Structures of muscimol (with numbers indicating positions of modification sites) and analogs modified at positions 3 and 4 of the ring structure. The effect on GABAA is based on previously published findings. b BMM were infected with Salmonella in the presence of indicated concentrations of muscimol or muscimol analogs. LDH released during cell lysis was measured and used to calculate the inhibitory percentage. Combined data from two independent experiments (mean ± SD, n = 3 per experiment) are shown.
