Fig. 6: Modification of muscimol at position 5 abolishes the inhibitory capacity of muscimol.
From: Muscimol inhibits plasma membrane rupture and ninjurin-1(NINJ1) oligomerization during pyroptosis
a Structures of muscimol analogs modified at position 5 of the ring structure that maintains activity at the GABAA receptor. b, c BMM were infected with Salmonella in the presence of indicated concentrations of muscimol or muscimol analogs. LDH released during cell lysis was measured and used to calculate the inhibitory percentage. Combined data from two independent experiments (mean ± SD, n = 3 per experiment) are shown.
