Fig. 4: Aggregation propensity of models. | Communications Biology

Fig. 4: Aggregation propensity of models.

From: “Redirecting an anti-IL-1β antibody to bind a new, unrelated and computationally predicted epitope on hIL-17A”

Fig. 4: Aggregation propensity of models.

a Model of clone 11.4_C12. b Model of a triple mutant of this clone (L_Y93N, L_W94N, L_S95G) showing an improved aggregation propensity prediction. The surfaces of the models are color-coded according to the calculated aggregation propensity, based on an implementation of the SAP method, with red indicating the aggregation-prone regions. A green circle marks the area of the mutations.

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