Fig. 3: Stress-induced deactivations in the posterior insula and substantia nigra are stronger with increasing BMI.
From: Stress-induced brain responses are associated with BMI in women
a Whole-brain regression analyses (n = 190) show associations between body mass index (BMI) and stress-induced (Stress – PreStress) activation changes. Higher BMI is associated with increased (warm colors) stress-induced activation in the superior parietal lobe/precuneus and decreased (cool colors) activation in the substantia nigra and posterior insula. Voxel-threshold for display: p < 0.001, t > 3.13. b Extracted beta estimates (average across the region of interest, ROI) from corresponding ROIs defined in the Shen atlas49 are negatively associated with BMI. Regression weights and significance values are derived from separate multiple regressions for n = 120 females and n = 70 males (accounting for confounds and data is shown unadjusted for the visualization). Shaded areas show 95% confidence intervals for the associations of unadjusted data. Associations with BMI are only significant in females. BMI = body mass index, L = left, R = right. Source data are provided in the Supplementary Data 1.
