Fig. 1: Landscape of alternative splicing (AS) in T. marneffei-infected THP-1 macrophages.

a The numbers of different types of AS events in T. marneffei-infected and -uninfected THP-1 macrophages at 24 h post-infection. The left panel represents all AS events and significant differentially AS events (FDR < 0.05), the right panel represents the distribution of significant differentially AS events (FDR < 0.05) in macrophages with or without T. marneffei infection. b UpSet plot (an alternative Venn diagram) of different types of significant AS genes in T. marneffei-infected THP-1 macrophages at 24 h post-infection. The black bars on the left represent the numbers of each type of AS events. The black dots in the matrix at the right represent the intersections of AS events. The black dot-lines indicate the gene may have one or more alternative splicing patterns. c Chord diagram of the abundance of KEGG pathways according to ES-type AS genes with FDR < 0.05 and |Lnclevel| > 0.5 after infection of T. marneffei for 24 h. Supplementary material is available (Supplementary Fig. 1; Supplementary Data 1). AS, alternative splicing; ES exon skipping, RI retained intron, A5SS alternative 5’splice site, A3SS alternative 3’splice site, MXE mutually exclusive exon splicing, Tm T. marneffei.