Fig. 8: Schematic diagram: TUT1-mediated alternative splicing produces a truncated protein NCOR2-013 that suppresses T. marneffei-stimulated macrophage inflammation. | Communications Biology

Fig. 8: Schematic diagram: TUT1-mediated alternative splicing produces a truncated protein NCOR2-013 that suppresses T. marneffei-stimulated macrophage inflammation.

From: Talaromyces marneffei suppresses macrophage inflammation by regulating host alternative splicing

Fig. 8: Schematic diagram: TUT1-mediated alternative splicing produces a truncated protein NCOR2-013 that suppresses T. marneffei-stimulated macrophage inflammation.The alternative text for this image may have been generated using AI.

T. marneffei infection of macrophages promoted AS of NCOR2, in which TUT1 is an AS regulator, and NCOR2-013, a truncated protein of NCOR2/SMRT, was significantly upregulated after T. marneffei infection. Mechanistic analysis reveals that NCOR2-013 forms a co-inhibitory complex with TBL1XR1/TBLR1 and HDAC3. Consequently, this complex inhibits the JunB-mediated transcriptional activation of pro-inflammatory cytokines by suppressing histone acetylation, thereby regulating the expression of inflammatory factors such as IL-1β and TNF-α.

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