Fig. 5: Neutralization of S proteins from human and bat CoVs.
From: Determinants of species-specific utilization of ACE2 by human and animal coronaviruses
a Neutralization of VSVpp carrying the S proteins of the indicated human and bat CoVs by sera obtained from five AZ/BNT/BNT (upper) or five 3xBNT (lower) vaccinated individuals compared to the untreated control (set to 100%). Shown are mean values obtained for the five sera, each tested in at least two technical replicates. Infection was measured in HEK293T cells expressing human or bat (right panel) ACE2. b IC50 values obtained for neutralization of the indicated S proteins by individual sera as described under (a). Symbols indicate individual donors and orange lines the average value obtained for the five sera from the respective groups. c Correlation between the IC50 values obtained for the AZ/2xBt and 3xBt groups. Human S proteins are indicated by red and bat S proteins by black symbols. Percentages indicate amino acid identity to the SARS-CoV-2 S protein.
