Fig. 6: Overview on ACE2 usage by CoV S proteins and possible cross-species transmissions.
From: Determinants of species-specific utilization of ACE2 by human and animal coronaviruses
a Binned heatmap of the infection efficiency of various ACE2-S combination. Data aggregated from Figs. 2a, 3a, and 4a. b Chord diagram of the data in (a) depicting the efficiency of indicated S-ACE2 mediated infection as scaled connectors. Left panel: SARS-CoV-2 Hu-1 (blue) and Variants of concern (Delta, red; Omicron, purple and green). Right panel: assorted SARS-CoV-2-related CoVs (blue and purple) and SARS-CoV-1-related CoVs (red) compared to bat CoVs (gray). Species of ACE2 as indicated in the lower half of the panel.
