Fig. 3: Chromatin accessibility dynamics during the growth of postnatal muscle.

a PCA plot summarizes the relationship among ATAC-seq samples. b The density plot summarizes the signal difference (of mean read counts) of DAR and a pie plot for their distribution on different genomic features (gene body, distal regions, downstream and upstream of the gene) in all comparison groups. The genome was divided into four regions: upstream region (including TSS-3kb and 5’ UTR), gene body, downstream region (downstream and 3’ UTR), and distal region (distal intergenic region). Taking D3-M3 as an example, the increased red area curve indicates stronger accessibility of the DARs in M3 (logM3-logD3 > 0) and, 41.2% DAR lies in distal intergenic regions. c Upset plot summarizing the distribution of DAG in all comparison groups. d GO items for all comparison groups in (c). The same category was grouped and labeled aside. e Genes regulated by chromatin accessibility (or transcriptionally consistent DAR) were divided into two groups: co-upregulated genes (in the first quadrant) and co-downregulated genes (in the third quadrant) at different genomic feature facets. Co-regulated genes at specific stages (D3-M3, D3-M6, and D3-M12) were in different colors. DAR differentially accessible regions, DAG differential accessible genes, TSS transcription start site, UTR untranslated region.