Fig. 4: DMF favors serine and glycine synthesis from glucose in the absence of extracellular serine and glycine in HMECs. | Communications Biology

Fig. 4: DMF favors serine and glycine synthesis from glucose in the absence of extracellular serine and glycine in HMECs.

From: New insights in the targets of action of dimethyl fumarate in endothelial cells: effects on energetic metabolism and serine synthesis in vitro and in vivo

Fig. 4: DMF favors serine and glycine synthesis from glucose in the absence of extracellular serine and glycine in HMECs.

A Fractional labeling of serine from [U-13C]-glucose, (B) intracellular serine levels, (C) fractional labeling of glycine from [U-13C]-glucose, (D) intracellular glycine levels, (E) fractional labeling of 3-PG from [U-13C]-glucose and (F) intracellular 3-PG levels in cells treated with 100 μM DMF for 24 h in the presence or absence of extracellular serine and glycine. Data are expressed as means ± SD for an experiment with three replicates. Statistical significance was determined using the unpaired, two-sided Student t test and the resulting p values are shown in the figure as follows: *p < 0.05; **p < 0.01; ***p < 0.001; ***p < 0.0001 versus condition with extracellular serine and glycine. ns: non-significant.

Back to article page