Fig. 5: Proposed mode of action of JNJ-8003. | Communications Biology

Fig. 5: Proposed mode of action of JNJ-8003.

From: Structural and mechanistic insights into the inhibition of respiratory syncytial virus polymerase by a non-nucleoside inhibitor

Fig. 5

a Zoomed-in view of JNJ-8003 binding site with the priming and intrusion loops colored in red and green, respectively. Side chains of substitutions in the capping domain that cause defects in transcription and replication were shown. Side chain of S1266 forming direct interaction with JNJ-8003 was shown. b Overlay of RSV L derived from AlphaFold2 (Supplementary Fig. 14c), VSV L initiation complex72 models, and RSV L + P with JNJ-8003 bound structure. The priming loop was highlighted in magenta or green for pre-initiation/initiation or elongation states, respectively. The transition of the priming loop was indicated using curve arrow. RNA template, dinucleotides, and metal ions were shown in cartoons, sticks, and spheres, respectively. The L659T660R661 and G810D811N812 regions were highlighted. JNJ-8003 was shown in yellow sticks.

Back to article page