Fig. 1: Summary of HLA alleles and their distribution per genetic ancestry. | Communications Biology

Fig. 1: Summary of HLA alleles and their distribution per genetic ancestry.

From: HLA allele-calling using multi-ancestry whole-exome sequencing from the UK Biobank identifies 129 novel associations in 11 autoimmune diseases

Fig. 1: Summary of HLA alleles and their distribution per genetic ancestry.The alternative text for this image may have been generated using AI.

a Number of 3-field HLA alleles per continental genetic ancestry. b Number of 3-field HLA alleles per genetic ancestry, divided by the number of participants in each ancestry. c Cumulative 3-field allele frequency. Each line represents a different HLA gene. Dashed line at 90%. Note that some genes are not present in all participants (e.g., HLA-DRB3), and their true cumulative allele frequency sum would be less than 100%. Hence, frequencies are given as allele count for allele divided by total number of alleles at that gene, then added cumulatively starting with the alleles with the highest frequencies. d The average number of alleles per gene stratified by HLA class. e The average number of alleles per gene divided by the number of participants in each cohort stratified HLA class. All analyses in this figure were limited to the protein-coding genes.

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