Fig. 4: Expression of clustering impaired KV2.1S590A does not affect KV2.1 channel activity in arterial myocytes. | Communications Biology

Fig. 4: Expression of clustering impaired KV2.1S590A does not affect KV2.1 channel activity in arterial myocytes.

From: The formation of KV2.1 macro-clusters is required for sex-specific differences in L-type CaV1.2 clustering and function in arterial myocytes

Fig. 4

Computationally modeled IKv2.1 in male (a) and female (b) myocytes assuming 100% (red), 50% (blue) or 10% (green) of KV2.1 channels present in the plasma membrane are functional. Computationally modeled IKv2.1 in male (c) and female (d) myocytes assuming 1% (gray) and 0.1% (black) KV2.1 channels are functional. e Representative IKv2.1 traces at +50 mV from KV2.1WT male (black) and KV2.1S590A male (purple) arterial myocytes and voltage dependence of IKv2.1 in KV2.1WT (black) and KV2.1S590A (purple) male myocytes from −50 to +50 mV. f Representative IKv2.1 traces at +50 mV from KV2.1WT female (red) and KV2.1S590A (blue) arterial myocytes and voltage dependence of IKv2.1 in KV2.1WT (red) and KV2.1S590A (blue) female myocytes from −50 to +50 mV. IKV2.1 traces were obtained by subtracting currents after the application of RY785 from control IK traces. n = 18 KV2.1WT male, 6 KV2.1S590A male, 19 KV2.1WT female and 13 KV2.1S590A myocytes. Error bars indicate mean ± SEM.

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