Fig. 6: CaV1.2 cluster sizes are decreased in myocytes from female but not male KV2.1S590A mice. | Communications Biology

Fig. 6: CaV1.2 cluster sizes are decreased in myocytes from female but not male KV2.1S590A mice.

From: The formation of KV2.1 macro-clusters is required for sex-specific differences in L-type CaV1.2 clustering and function in arterial myocytes

Fig. 6: CaV1.2 cluster sizes are decreased in myocytes from female but not male KV2.1S590A mice.The alternative text for this image may have been generated using AI.

a Representative super-resolution GSD images of immunolabeled CaV1.2 labeled channels in KV2.1WT and KV2.1S590A male myocytes. Insets show 4 μm2 regions of interest. b Relative frequency as a percentage of CaV1.2 cluster areas of KV2.1WT (black) and KV2.1S590A (purple) in male myocytes. c Summary plot of mean CaV1.2 cluster areas in male myocytes (n = 13 KV2.1WT and 14 KV2.1S590A male myocytes). d Representative super-resolution GSD microscopy images of immunolabeled CaV1.2 labeled channels in KV2.1WT and KV2.1S590A female myocytes. e Relative frequency as a percentage of CaV1.2 cluster areas of KV2.1WT (red) and KV2.1S590A (blue) female myocytes. f Summary plot of mean CaV1.2 cluster areas in female myocytes (n = 12 KV2.1WT and 9 KV2.1S590A female myocytes). *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001. Error bars indicate mean ± SEM.

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