Fig. 4: Interaction between peptides and LPS. | Communications Biology

Fig. 4: Interaction between peptides and LPS.

From: A cleavable chimeric peptide with targeting and killing domains enhances LPS neutralization and antibacterial properties against multi-drug resistant E. coli

Fig. 4

a Binding affinity of R7, L7, LBP14, LBP14-RKRR, “LBP14-RKRR + L7”, “LBP14 + L7”, and PMB to LPS. The results are given as the mean ± SD of three independent experiments. Different lower-case letters indicate a significant difference between the two groups (p < 0.05). b Putative binding sites of LBP14-RKRR, L7, and R7 with LPS. Docking was performed using Autodock vina. Up: complex structures of LBP14-RKRR, L7 or R7 and LPS. Oxygen, carbon, hydrogen atoms are indicated as red, green and white, respectively. Down: H-bonding between the peptides and LPS. LPS and peptide chains are shown as green and blue, respectively. The hydrogen bonds are shown in yellow dotted lines.

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