Fig. 8: Effects of cleavable chimeric peptide R7 on lung injury in mice. | Communications Biology

Fig. 8: Effects of cleavable chimeric peptide R7 on lung injury in mice.

From: A cleavable chimeric peptide with targeting and killing domains enhances LPS neutralization and antibacterial properties against multi-drug resistant E. coli

Fig. 8

Mice were intraperitoneally injected with 7 μmol/kg different peptides (including R7, L7, LBP14-RKRR, the “LBP14-RKRR + L7 combination, respectively) at 0 h (three mice/group), followed by injection with LPS (13.5 mg/kg) at 6 h. Lung injury was analyzed histologically at 12 h or 24 h, respectively. a Histopathological images of lung sections after staining with hematoxylin and eosin (H&E). Images are presented at a magnification of 100×. b Pathological analysis of lung. Lung injury involves in inflammation (such as peribronchial, perivascular, intrabronchial, and pulmonary interstitial one), bronchial exudate, and alveolar septal thickening, respectively. The specific degree of lung injury of each mouse is assessed by Score 0 (asymptomatic), Score 1 (mild), Score 2 (moderate), and Score 3 (severe), respectively. c The number of counted infiltrated inflammatory cells within processed lung sections from (a). Data represent the mean ± SD of three independent experiments. Different lower-case letters indicate a significant difference between the two groups (p < 0.05).

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