Table 1 Sequence and physicochemical properties of cleavable/non-cleavable chimeric peptides.

From: A cleavable chimeric peptide with targeting and killing domains enhances LPS neutralization and antibacterial properties against multi-drug resistant E. coli

Peptide

Sequence

Characteristic

MW (Da)

Charge (+)

pI

GRAVY

AI

BI (kcal mol-1)

Hydrophobicity

LBP14

RVQGRWKVRASFFK

LPS-binding peptide

1765.10

5

12.31

-0.793

48.57

3.26

0.236

LBP14-RKRR

RVQGRWKVRASFFK-RKRR

LPS-binding peptide with cleavable linker

2361.83

9

12.70

-1.583

37.78

5.33

-0.039

L7

FKAWRWAWRMKKLAAPS

Antibacterial peptide

2133.59

5

12.02

-0.594

46.47

1.49

0.494

R7

LBP14-RKRR-L7

Chimera of LBP14 and L7 via a cleavable linker (RKRR)

4477.41

14

12.85

-1.103

42.00

3.46

0.220

A7

LBP14-(EA3K)2-L7

Chimera of LBP14 and L7 via a rigid linker ((EA3K)2)

4821.72

10

11.86

-0.615

50.49

2.07

0.251

G7

LBP14-G4S-L7

Chimera of LBP14 and L7 via a flexible linker (G4S)

4195.96

10

12.61

-0.656

40.83

1.96

0.324

  1. “RKRR”: cleavable linker, “(EA3K)2” and “G4S”: non-cleavable linker, MW molecular weight, pI isoelectric point, GRAVY grand average of hydropathicity, AI aliphatic index, BI Boman index.
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