Table 2 MIC and MBC values of the peptides.

From: A cleavable chimeric peptide with targeting and killing domains enhances LPS neutralization and antibacterial properties against multi-drug resistant E. coli

Strains

LBP14

LBP14-RKRR

L7

R7

LBP14 + L7 a

LBP14-RKRR + L7 a

PMB

A7 b

G7 c

MIC (μM)

MBC (μM)

MIC (μM)

MBC (μM)

MIC (μM)

MBC (μM)

MIC (μM)

MBC (μM)

MIC (μM)

MBC (μM)

MIC (μM)

MBC (μM)

MIC (μM)

MBC (μM)

MIC (μM)

MBC (μM)

MIC (μM)

MBC (μM)

Gram-negative bacteria

Escherichia coli CVCC195 d

4.53

4.53

2.26

2.26

2.26

4.53

1.13

1.13

1.13

2.26

1.13

2.26

1

1

36.2

36.2

18.1

18.1

S. typhimurium CVCC533

18.1

18.1

4.53

128

18.1

18.1

1.13

2.26

4.53

4.53

4.53

4.53

8

8

>36.2

>36.2

>36.2

>128

Gram-positive bacteria

Staphylococcus aureus ATCC43300 b

36.2

36.2

4.53

64

18.1

18.1

2.26

2.26

9.06

9.06

2.26

2.26

>64

>64

>36.2

>36.2

>36.2

>36.2

S. aureus CVCC546 b

36.2

>36.2

9.06

9.06

18.1

36.2

2.26

2.26

4.53

4.53

2.26

2.26

>64

>64

>36.2

>36.2

>36.2

>36.2

  1. a1:1 mixture of LBP14 (or LBP14-RKRR) and L7.
  2. bA7: connect LBP14 and L7 via rigid linker (EA3K)213.
  3. cG7: connect LBP14 and L7 via flexible linker G4S13.
  4. dThe strains are resistant to different antibiotics13,62. The MDR E. coli CVCC195 strain is resistant to doxycycline, benzocillin, penicillin, lincomycin, clindamycin, vancomycin, chloramphenicol, erythromycin, amikacin, streptomycin, gentamicin and sulfamethoxazole, respectively. The S. aureus ATCC43300 strain is resistant to lincomycin, amoxicillin, amikacin, ampicillin, oxacillin, erythrocin, sulfisoxazole, neomycin, azithromycin, kanamycin, gentamicin, and penicillin, respectively. The S. aureus CVCC546 strain is resistant to tetracycline, bacitracin, and sulfisoxazole, respectively.
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