Fig. 6: Expression levels of the genes encoding monoamine-regulating enzymes in the brain of SMNΔ7 mice at post-natal day 11. | Communications Biology

Fig. 6: Expression levels of the genes encoding monoamine-regulating enzymes in the brain of SMNΔ7 mice at post-natal day 11.

From: SMN deficiency perturbs monoamine neurotransmitter metabolism in spinal muscular atrophy

Fig. 6: Expression levels of the genes encoding monoamine-regulating enzymes in the brain of SMNΔ7 mice at post-natal day 11.The alternative text for this image may have been generated using AI.

a–d Transcript levels of a Tyrosine hydroxylase (Th; n = 7 WT, n = 10 SMNΔ7), b Dopamine β hydroxylase (Dβh; n = 8 WT, n = 10 SMNΔ7), c Tryptophan hydroxylase 2 (Tph2; n = 7 WT, n = 10 SMNΔ7) and d Aromatic amino acid decarboxylase (Aadc; n = 8 WT, n = 10 SMNΔ7) in the brain of SMNΔ7 mice and wild-type (WT) littermates at post-natal day 11. e–h Transcript levels of e Tyrosine hydroxylase (Th), f Dopamine β hydroxylase (Dβh), g Tryptophan hydroxylase 2 (Tph2) and h Aromatic amino acid decarboxylase (Aadc) in the brain of SOD1 and wild-type (WT) littermates at post-natal day 120 (n = 6/genotype). Data are expressed as the difference in threshold cycle (2-ΔΔCt) between the target gene and the reference gene, β-glucuronidase (Gusb) (arbitrary units, AU), and shown as box and whisker plots representing median with interquartile range (IQR). Dots represent individual mice values. *p < 0.05, **p < 0.01, compared with age-matched WT mice (unpaired t-test).

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