Fig. 1: ECF group-II transporters and compound 1.
From: Identification of inhibitors targeting the energy-coupling factor (ECF) transporters
a Architecture of ECF group-II transporters. In yellow the S-components (e.g., the ones specific for folic acid (FolT) and panthotenate (PanT)), in red EcfA, in pink EcfA´ and in light blue EcfT, grouped in blue is the ECF module (EcfT, EcfA and EcfA´). The S-components interact with a shared ECF module. b Chemical structure of compound 1 identified through structure-based virtual screening using the crystal structure of Lactobacillus delbrueckii ECF-FolT2 (PDB ID 5JSZ)29.
