Fig. 6: TDPs of A2AAR, A2AAR[D52N], A2AAR[I92N], and A2AAR[R291Q] in the presence of mini-GS. | Communications Biology

Fig. 6: TDPs of A2AAR, A2AAR[D52N], A2AAR[I92N], and A2AAR[R291Q] in the presence of mini-GS.

From: Single-molecule visualization of human A2A adenosine receptor activation by a G protein and constitutively activating mutations

Fig. 6: TDPs of A2AAR, A2AAR[D52N], A2AAR[I92N], and A2AAR[R291Q] in the presence of mini-GS.The alternative text for this image may have been generated using AI.

TDPs were generated from the normalized initial and final intensities. a The TDPs of A2AAR without ligand added (apo), in complex with the antagonist ZM241385 and in complex with the agonist NECA in the presence of mini-GS. The X and Y axes of the TDP plots represent the normalized initial and final intensities of transition events. The gradient color scheme is indicated in the color bars, where the arrowhead points toward a relatively higher density, which relates to the frequency of observed transitions. “n” refers to the number of analyzed transitions. b–d TDPs for b A2AAR[D52N], c A2AAR[I92N], and d A2AAR[R291Q] in the presence of mini-GS. Same presentation details as in (a).

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