Fig. 2: The starch/AMG hydrogel environment extends survival of hMSCs by delivering glucose in near anoxia in vitro.
From: Enzyme-controlled, nutritive hydrogel for mesenchymal stromal cell survival and paracrine functions
a, b Viability of hMSCs seeded in either glucose-free hydrogels or hydrogels with increasing starch concentrations either with a or without b AMG, after exposure to near-anoxia (0.1% pO2). (n = 3). c Viability of hMSCs seeded in either glucose-free, 5.5 mM glucose, or starch 2%/AMG hydrogels after exposure to near-anoxia for 7 and 14 days. (n = 4–9) d. Viability of hMSCs seeded in either glucose-free, 5.5 mM glucose, or starch 2%/AMG hydrogels after exposure to 2-Deoxy-D-Glucose (a competitive inhibitor for the production of glucose-6-phosphate) in near-anoxia for 3 days. (n = 3).
