Fig. 2: Epithelial origin tumors exhibit four EMT subtypes. | Communications Biology

Fig. 2: Epithelial origin tumors exhibit four EMT subtypes.

From: Tumor microenvironment remodeling plus immunotherapy could be used in mesenchymal-like tumor with high tumor residual and drug resistant rate

Fig. 2: Epithelial origin tumors exhibit four EMT subtypes.

a Unsupervised consensus cluster of 9415 samples across 24 cancer-types based on 35 EMTCGs classified tumors into four subtypes. b Comparison of mesenchymal transition activity among four clusters. The mesenchymal transition activity was significantly up-regulated in Cluster III and IV; the Student’s t test was used to analyze statistical significance; Cluster I, n = 1864; Cluster II, n = 3094; Cluster III, n = 1532; Cluster IV, n = 2925. c Distribution of individual cancer samples among four different EMT clusters. d Kaplan-Meier curve of overall survival of patients with different EMT subtypes for TCGA datasets; Cluster I, n = 1864; Cluster II, n = 3094; Cluster III, n = 1532; Cluster IV, n = 2925; Cluster III was statistically associated with unfavorable survival outcome. e Summarization of biological features among four EMT clusters.

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