Fig. 7: Lipid dysregulation induced by Mtb infection and the TB progression. | Communications Biology

Fig. 7: Lipid dysregulation induced by Mtb infection and the TB progression.

From: LiLA: lipid lung-based ATLAS built through a comprehensive workflow designed for an accurate lipid annotation

Fig. 7

a LINEX Lipid network of the mice lung tissue with node colored by lipid classes. Keeping the same lipid distribution within the networks, plots B and C represent node size scaled by −log10 of FDR and colored by fold change for the comparison between (b) Mtb+4w (n = 6) vs Mtb− (n = 6), and (c) Mtb+12w (n = 5) vs Mtb− (n = 6). Blue colors indicate lower concentrations of lipids. All edge connections are colored by reaction type as follows: chain length (blue), desaturation (orange), FA addition (green), head group modification (red). d–f Bar chart with the experimental values of PI (d), BMP (e), and PG (f) lipid species in each group. The error bars represent the standard error of the mean (SEM). *p ≤ 0.05; **p ≤ 0.01; ***p ≤ 0.001; ns, not significant in the comparison.

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